Storm the heart of downtown SF with a stay at the eclectic-themed Clift Hotel. Both style and substance, the famed Redwood Room lounge and Velvet Room restaurant feature locally sourced ingredients. For a swanky take on business travel try the W San Francisco, located south of Market and home to the trendy yet hassle-free XYZ lounge.
Famous for its outstanding cuisine, you can't go wrong with the Italian/French tasting menu at Quince, a burger at Wayfare Tavern, or breakfast pastries at Tartine. For a once-in-a-decade splurge, head to Napa Valley's famous French Laundry where chef Thomas Keller presides over each fastidiously crafted, exquisite course.
From the gorgeous lobby of the St. Regis to the waterfront Waterbar and open-air patio at B, you're never too far from a fabulous martini. For vigilant mixology and classes in cocktailing, hit Alembic or Bourbon & Branch, sister of NYC's Milk & Honey. And when only champagne will do, head to the exhaustive Bubble Lounge in the Financial District.
Catch indie acts like the Raveonettes, Dilettantes, and Warlocks at Bottom of the Hill, The Independent, and Cafe du Nord. For a more electronic scene, hop a cab to Mighty, Mezzanine, or 111 Minna. Of course, keep your ears peeled for the afterparty – (we've landed anywhere from hipster Victorians to mansions with indoor pools).